A lab-in-the-loop platform for AI optimization of RNA therapies
Expression profile is a primary determinant of therapeutic success, but most RNA sequences are still optimized using outdated single-variable approaches, leaving significant performance potential unrealized. Achieving high expression and durability requires balancing multiple interdependent factors simultaneously: translation dynamics, RNA secondary structure, and genetic element interactions.
RNA Edge was built to solve this multi-dimensional design problem. It's a fully integrated system for optimization of expression profile, with every design validated in application-relevant cell types.
We deliver high-confidence RNA designs in weeks.
Benefits of RNA Edge
End-to-end RNA optimization
- AI sequence optimization, novel genetic parts, and experimental validation to improve expression profile.
Broad therapeutic applicability
- Supports linear mRNA and circular RNA across cell therapy, genome editing, and vaccines.
Proven performance
- Validated in large biopharma programs for CAR and Cas9.
Ready to optimize your RNA
therapeutic?
Precise control to drive therapeutic success
Expression profile is a primary determinant of therapeutic success, but achieving the right level, timing, and cell specificity requires optimizing across multiple interdependent biological factors simultaneously. RNA Edge combines proprietary computational models, high-performance genetic parts, and integrated lab screening to systematically explore design space and deliver high-performing candidates across every axis of expression.
Key capabilities
Multi-objective codon optimization
- Up to 9x higher expression by optimizing multiple biological factors.
Genetic parts
- Internal ribosome entry site (IRES) and untranslated region (UTR) design and screening capabilities.
Validation in relevant cells
- Integrated in vitro screening in application-relevant cell models provides greater insight into real-world therapeutic performance.
Why choose RNA Edge?
Optimization outcomes
Expression level
- Increased expression to achieve the optimal profile.
Duration and stability
- Greater control over RNA half-life and temporal dynamics.
Cell type expression profiling
- Exploration and understanding of differential expression across cell types.
How it works
RNA Edge is an end-to-end integrated platform that delivers top candidates in weeks.
1
AI-guided sequence optimization
Variants generated using Asimov’s proprietary machine learning models, multi-objective codon optimizer, and genetic parts.
2
RNA production
Integrated production and purification of RNA sequence variants.
3
Hit generation primary screen
All variants screened in cell-based assays. Top candidates nominated.
4
Hit-to-lead validation screen
Top hits validated with concentration dependent expression profiling.
5
Delivery of optimized candidates
Optimized sequences transferred with full data package, ready for your next stage.
